Abstract
Abstract
Renal function following saline infusion (10% body wt) has been studied in four groups of rats 3 to 5 days after operation: Sham (S), Adrenal Enucleation (AE), Unine-phrectomy (N), and AE + N. The purpose of the study was to clarify the mechanisms of the effect of N on sodium excretion in AE. AE excreted significantly less sodium, 6.7 ± 1.3 μEq/min, than S, 29.7 ± 2.7 μEq/min. Sodium excretion by N, 25.4 ± 5.3 μEq/min and AEN, 19.4 ± 3.2 μEq/min were not different from each other or S, but greater than AE (P < 0.01). When AE (two kidneys) was compared with AEN (one kidney), the filtered sodium was not significantly different. Thus, it is concluded that the greater natriuresis in AEN versus AE is most likely secondary to a difference in tubular sodium reabsorption. Renal function following saline infusion (10% body wt) has been studied after the development of adrenal regeneration hypertension (6 weeks postsurgery) in AEN rats and their control groups N. Mean blood pressure was significantly elevated in the AEN group, 161 ± 4 versus 128 ± 3 mmHg. The sodium excretion was not different between the two groups. It is concluded that rats with adrenal regeneration hypertension do not have an exaggerated natriuresis as has been described in other forms of experimental hypertension.
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