Abstract
Summary
The effects of plasma from patients with spondyloarthropathies on Con A-induced transformation of PBMC from normal individuals were evaluated. Plasma from untreated patients did not produce a significant difference in responsiveness when compared with normal autologous plasma, while plasma from patients treated with phenylbutazone caused a significant decrease in PBMC responsiveness. It is not clear whether this phenomenon is mediated by effects on prostaglandin metabolism or through other mechanisms.
The authors wish to thank Dr. Arnold Powell for his advice and Ms. Ann Brandt for her help in the preparation of the manuscript. These studies were supported by the Irma H. Bender Arthritis Research Fund.
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