Abstract
Summary
The natriuretic activities of several synthetic analogs of oxytocin having a 7-glycine substitution and some analogs having a different single amino acid substitution or a deletion were tested in conscious, saline-loaded rats. The 7-glycine-substituted analogs and [8-proline]-oxytocin all possessed similar natriuretic activities, 2–8% of the natriuretic activity of oxytocin. [2-Phenylalanine]-oxytocin, however, possessed 26% of the natriuretic activity of oxytocin. Des-9-glycinamide-oxytocin retained about 0.2% of the natriuretic activity of oxytocin. The natriuretic and oxytocic or antidiuretic activities of these analogs were not linearly correlated. The natriuretic response to oxytocin analogs thus appears to be mediated by receptors which are different from the oxytocic and antidiuretic receptors for these peptides.
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