Abstract
Summary
A partial purification of natriuretic factor from volume-expanded rat kidney has been achieved by Sephadex gel chromatography and acrylamide gel electrophoresis. This factor inhibits frog skin SCC and Na-K-ATPase from different sources in a dose-dependent manner. Activity is destroyed by incubation with trypsin or fresh kidney homogenate but not chymotrypsin.
This work was supported by a group investigative award from the American Heart Association, Los Angeles affiliate. The authors are indebted to Ms. De-Anna Mackey and Ruby McCarty for secretarial assistance.
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