Abstract
Summary
Plasma renin activity (PRA) and the levels of urinary kallikrein (UK) were studied simultaneously in Goldblatt one- and two-kidney hypertensive rats (1KG and 2KG) 5, 10, and 15 weeks after clamping the left renal artery.
Increase in PRA was statistically significant in 2KG rats (P < 0.0005 on the 5th and 10th week, and P < 0.002 on the 15th week). PRA was not significantly different to that of controls in 1KG rats. Contrariwise, the urinary kallikrein levels were significantly lower in 1KG rats (P <0.002) in relation to values found in normotensive rats.
In 2KG rats, urinary kallikrein levels became significantly lower than those in controls only 15 weeks after surgery.
Special acknowledgment to Prof. M. L. Forcelledo for her criticism and for the great help in performing the AI R.I.A. procedure. This work was supported by D.I.U.C. 308/77 and P.N.U.D.-U.N.E.S.C.O., RLA 76/006 Grants.
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