Abstract
Summary
Acute neutropenia was induced in five dogs using an antineutrophil serum prepared in rabbits. Sera obtained at various times after injection were assayed for their capacity to stimulate or inhibit mouse bone marrow cell colony formation in vitro. The results indicated that serum colony stimulating factor (CSF) in the dog is inversely related to the number of blood neutrophils and that a serum inhibitor closely paralleled the change of neutrophils in blood. These results suggest that both CSF and a serum inhibitor are involved in the regulation of granulopoiesis.
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