Abstract
Summary
The effect of ethanol administration on polyribosomes and in vitro protein synthesis of host liver and hepatoma was investigated. When Buffalo rats bearing hepatoma 5123 intrahepatically were tube-fed ethanol (0.75 g/100 g body wt as a 50% (v/v) solution in saline) 3 hr before killing, there was disaggregation of total polyribosomes and a decrease in in vitro protein synthesis ([14C]leucine incorporation into protein) in hepatoma but not in host liver in comparison with control groups. Evaluation of the disaggregation of the polyribosomes of the hepatoma of the ethanol-treated rats revealed that the membrane-bound fraction was affected more than the free fraction.
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