Abstract
Summary
Potential antiobesity oral agent 3-phenylpropylaminoguanidine HCl (43–522) was further investigated for its effects on carbohydrates other than glucose, amino acids, and fatty acid absorption in rats. The present experiments were conducted to evaluate its action on absorption of galactose, maltose, lactose, sucrose, and starch. Fructose absorption, as measured by hypertriglycemia was prevented by 43–522 treatment. The 43–522 did not affect the active amino acid (methionine) transport in vitro. The fatty acid (palmitic acid) absorption was not significantly influenced by 43–522 treatment as the total 14C radioactivity recovered over a period of 24 hr in thoracic duct lymph was unchanged. Therefore, 43–522, 3-phenylpropylaminoguanidine HCl, is a useful antiobesity agent which inhibits carbohydrate absorption in the rat.
The technical assistance of Mrs. Carol Meserve, B.S. and Mr. Jack Wiseberg, M.S., is greatly appreciated as is Dr. L. D. Boyajy for his criticism in the preparation of this manuscript. We also wish to thank Ms. Ginny Gross for her secretarial assistance in preparing this manuscript.
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