Abstract
Summary
The level of renal kallikrein activity in the rat has been determined at different times after a single NaCl loading by gavage.
The renal kallikrein activity increased rapidly, reaching its maximum level of 6.71 ng of bradykinin equivalents/mg of protein about 5 min after treatment and returning to control level, 1.11 ng of bradykinin equivalents/mg of protein, 20 min after gavage.
The levels of renal kallikrein activity found in rats submitted to sham gavage demonstrates that the increase is not the consequence of a nonspecific response to the handling or the stress induced by the gavage.
The results suggest that NaCl ingestion promotes very rapid increase in the level of renal kallikrein activity through some unknown cellular mechanism.
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