The Quantitation of Hemorrhage in the Skin. Measurement of Hemorrhage in the Microcirculation in Inflammatory Lesions and Related Phenomena 1

Abstract

Summary

Cutaneous hemorrhage was quantitated using ⁵⁹Fe-labeled red blood cells. The red blood cells were labeled by injecting ⁵⁹Fe-ferrous citrate, preincubated with serum. Skin lesions were induced either in rabbits whose own red cells had been labeled or in animals which had been transfused with labeled cells. Hemorrhagic lesions were produced by injecting heat- or formalin-killed E. coli, lysates of human PMN-leukocyte lysosomes, trypsin or by eliciting the local Schwartzman reaction.