Abstract
Summary
The polar compounds acetone, dioxane, tetrahydrofuran, di-methylsulfoxide, trioctanoin, and polyoxyethylene sorbitan monooleate (Tween 80) induce the activity of hepatic dimethylnitrosamine-demethylase I, a mixed-function oxidase repressed by typi-cal inducer agents such as 3-methylcholanthrene and phenobarbital. The highest activity was reached with dioxane, which is also a weak inducer for arylhydrocarbon hydroxylase, an inducible mixed-function oxidase. On the other hand in vitro addition of the polar compounds (with the exception of trioctanoin) to the assay system strongly inhibits dimethyl-nitrosamine-demethylase I activity; in vitro addition of trioctanoin increases this enzyme activity.
This investigation was supported by Grant 922A from The Council for Tobacco Research U.S.A., Inc.
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