Lack of Relationship Between Toxicity and Bone Marrow Cell Colony Stimulating Activity of Endotoxin Preparations

Abstract

Summary

The release of colony stimulating factor (CSF) by endotoxin was studied using several endotoxin preparations differing greatly in their toxicities measured as mouse LD₅₀. No correlation was found between lethality and CSF release. It is concluded that the toxic effect of endotoxin is not required for the generation of CSF.

Furthermore, the component in the polysaccharide rich and lipid free, nonendotoxic, partially hydrolyzed endotoxin breakdown product (called PS), which can stimulate the CSF release in mice, is sensitive to periodate oxydation.