Abstract
Summary
A 10% soybean oil emulsion (Intralipid) when given intravenously was found to prolong pentobarbital-induced sleep time in rats. The prolongation of sleep time was dose and time dependent. Heparin increased the clearance of Intralipid emulsion from the plasma and decreased the amount of time by which sleep was prolonged. It was further demonstrated that pentobarbital anesthesia decreased the clearance of intravenously administered Intralipid emulsion from the plasma. Thus, a reciprocal interaction was observed whereby pentobarbital prolonged the half-life of Intralipid emulsion and Intralipid emulsion prolonged the narcosis induced by pentobarbital.
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