Abstract
Summary
The influence of experimental lathyrism generated by β-aminopropionitrile (BAPN) treatment on matrix-induced endochondral ossification was investigated. Although the mesenchymal cell proliferation was not affected, BAPN was inhibitory to chondrogenesis as quantitated by 35SO4 incorporation. Both cartilage and bone mineralization, as indicated by 45Ca incorporation, were profoundly inhibited by BAPN treatment. The initial rate and the final extent of mineralization was impaired by the lathyrism. Matrices prepared from lathyritic bone and tooth were not as active as controls in induction of new bone as quantitated by alkaline phosphatase activity and 45Ca incorporation.
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