Abstract
Summary
The effects of three highly bound acids, viz salicylic acid, indomethacin, and dicloxacillin, on the binding of phenylbutazone to human plasma proteins were studied by equilibrium dialysis. Salicylic acid was found to displace phenylbutazone from its binding sites to a degree which might be clinically significant. Indomethacin caused a slight decrease in the percentage binding of phenylbutazone which is not likely to be of clinical importance. Dicloxacillin, however, did not appear to affect the plasma protein binding of phenylbutazone suggesting that the two drugs could be bound at mutually noninteracting sites in the protein molecule.
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