A Comparison of [ 35 S]Sodium Sulfate and [ 75 Se]Selenomethionine as Platelet Labels for the Assay of Thrombopoietin 1

Abstract

Summary

Platelet production rates were measured in thrombopoietin (TSF) assay mice by use of both [³⁵S]sodium sulfate and [⁷⁵Se]selenomethionine (⁷⁵SeM) as platelet labels. Although significantly higher values were found using Na₂ ³⁵SO₄ than ⁷⁵SeM, the incorporation patterns for both isotopes showed similarities in dose-response experiments.

The authors thank Marilyn Cottrell for expert technical assistance and Pat Taylor for stenographic aid.