Abstract
Summary
Estradiol binding activity has been measured in the rabbit corpus luteum on Days 2, 4, and 6 of pseudopregnancy. The results show that receptor activity is significantly greater on Day 4 than on Day 2 with continued increases on Day 6. In addition, the estradiol receptor activity is translocated into the nucleus within 30 min of injection of 100 μg of estradiol. Appreciable receptor translocation is observed following estradiol injection on Days 2, 4, and 6 of pseudopregnancy. It is concluded that estradiol binding activity in the rabbit corpus luteum is due to an authentic estradiol receptor and that a marked increase in this activity occurs by the 4th day of pseudopregnancy.
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