Abstract
Summary
Type-specific PCP vaccines (types 1 and 8) were fractionated twice on Sephadex G-200 to eliminate antigen of <70,000 M r and the vaccines were injected i.p. into rats. PCP of <70,000 M r was excreted in the urine within 72 hr after injection, and within 1 week most of the PCP in the urine was <70,000 M r. PCP in the urine had increased electrophoretic mobility and showed only partial immunologic identity in comparison with the injected PCP. Deposits of PCP in the renal mesangium and endothelium declined with time and were eventually eliminated from the tissue. These data indicate that types 1 and 8 PCP are slowly degraded in rats.
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