Abstract
Summary
Male New Zealand white rabbits with one-kidney one-clip Goldblatt hypertension of 3–5 weeks'duration were injected with purified tonin. Of 11 injected animals, 5 developed antibodies and in all of these animals blood pressure returned to normal levels. No change in blood pressure was observed in 6 animals in which no antibodies were detected. These findings are consistent with previous studies in rats and suggest that tonin plays a significant role in maintaining high blood pressure in one-kidney hypertensive animals.
The authors wish to thank Mrs. Suzanne Diebold, Miss Louise Lamarre, Miss Sylvie Duniol, and Mr. Michel Chamberland for the technical assistance and Mrs. Vivianne Lacombe for secretarial work. This work was supported by a Medical Research Council of Canada Group Grant to the Hypertension Multidisciplinary Group of the Clinical Research Institute of Montreal and the Quebec Heart Foundation (Dr. J. Gutkowska).
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