Abstract
Summary
The administration of cypro-heptadine to female rats transiently decreased serum GH levels. Forty-five minutes after cyproheptadine injection, in vitro GH synthesis and release was significantly decreased. Although cyproheptadine decreased PRL release in vitro, the drug had no direct in vitro inhibitory effect on GH release. Cyproheptadine did not affect the secretion of GH and PRL from transplantable tumor MtTW15, although it inhibited the in vitro release of GH from dispersed tumor cells. Cyproheptadine had no effect on either tumor size or the biological actions produced by the tumor hormones.
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