Abstract
Summary
The potentiation of CCl4-in-duced hepatotoxicity resulting from oral administration of methanol has been investigated in the rat. Results from the study demonstrate that methanol potentiates CCl4 hepatotoxicity to the same extent as that observed with isopropanol. It appears that the mechanism by which these two alcohols potentiate is similar in that they both increase covalent binding of CCl4 to microsomal proteins and lipids. However, the precise mechanism of potentiation remains as yet undetermined.
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