Abstract
Summary
Cloned L cells were shown to be very heterogeneous in their time and dose-responses to mouse interferon. Sensitive cells transferred interferon-induced viral resistance to less sensitive cells making them equally sensitive. A small fraction of cells was found to determine the overall response of the “parental” L-cell population. Based on these findings a new mechanism of interferon action on cells not in contact with interferon was proposed. The implications of this proposal to polypeptide hormone action are discussed.
The author thanks Cindy Harp for her expert technical assistance. This study was supported by U.S. Army Medical Research and Development Command Contract DAMD 17-78-C-8048.
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