Abstract
Summary
Albuterol, a specific β-2 adre-nergic agonist, was found to produce a significant increase in perfusate levels of Ep in isolated perfused dog kidneys which were programmed by prior exposure to hypoxia (0.42 atm) for 2 hr. Albuterol enhanced Ep titers in perfusates in both normoxemic and hypoxemic perfused kidneys which were significantly higher than that of the Ep level seen in saline controls during a 5-hr perfusion period. The effect of albuterol on Ep production in isolated perfused kidneys was abolished by pretreatment of the dogs with the prostaglandins synthetase inhibitor indo-methacin. The inhibition of albuterol-in-duced Ep elaboration by indomethacin supports our hypothesis that prostaglandins may play a significant role in mediating β-2 ad-renergic activation of kidney Ep production.
The expert technical assistance of Mr. Eugene Maulet is gratefully acknowledged.
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