Renal Denervation Eliminates the Renal Response to Continuous Positive-Pressure Ventilation 1

Abstract

Summary

A study was conducted to describe the role of the renal nerves in mediating the reflex antidiuresis and antinatriuresis associated with the application of continuous positive pressure ventilation (CPPV). Experiments were performed on seven dogs 4-5 days after they had undergone surgical de-nervation of the left kidney. The nerves to the right kidney were left intact. Urine flow (V), sodium excretion (U_naV), effective renal plasma flow (ERPF), and glomerular filtration rate (GFR) were determined for both the intact and denervated kidneys. In the right kidney with intact renal nerves, application of CPPV caused statistically significant (P <0.05) decreases from control levels in V, UnaV, ERPF, and GFR. In the left denervated kidneys, however, CPPV did not produce any statistically significant changes in V, U_naV, ERPF, or GFR. These data suggest that the renal nerves participate in mediating the antidiuresis and antinatriuresis associated with elevation of the expiratory pressure.