Abstract
Summary
There is a marked decrease in condensed chromatin clumps in HeLa cells treated with sodium n-butyrate for 24 hr. This change is rapidly reversible, with chromatin clumps reappearing 15 min after removal of the n-butyrate. These reversible morphological changes are closely correlated with hyper-acetylation of histones in n-butyrate-treated cells, and may represent a morphological expression of the biochemical modification of histones.
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