Abstract
Summary
Concanavalin A (Con A) and wheat germ agglutinin were tested for their ability to inhibit the polyethylene glycol-in-duced fusion of HEp2 cells. The inhibitory effect of these lectins was related to the concentration of lectins employed. Further studies with Con A revealed that the inhibition was also related to the available receptor binding capacity and the timing of the addition of the lectin. The presence of lectins in the early phase of the cell fusion process prevented the polyethylene glycol-treated cells from undergoing a fusion process.
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