Abstract
Summary
Total progressive antithrombin activity was significantly below normal in dogs with DIC and in aged Syrian hamsters with atrial thrombosis and consumption co-agulopathy. It was normal in healthy dogs with three types of inherited hemostatic defects: hemophilia A, VWD, and TT. These findings parallel those reported for humans with chronic diseases such as malignancy, thromboembolism, and DIC, and exemplify the potential of spontaneous diseases in animals as models for the study of human diseases.
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