Effects of Desferrioxamine on 67 Ga Distributions in Tumor-Bearing Mice

Abstract

Summary

The iron-chelating agent desferrioxamine caused approximately 10-fold reductions in ⁶⁷Ga vascular concentrations and substantial (~ × 2) reductions in ⁶⁷Ga concentrations of other tissues when injected iv into mice at 2 hr after ⁶⁷Ga injection. Given 48 hr post ⁶⁷Ga however, its only noteworthy effect was on the vascular compartment. Tumor was distinguished from other soft tissues by high concentrations of cell-bound ⁶⁷Ga, of which an appreciable fraction could be chelated and cleared by desferrioxamine given 2 hr after ⁶⁷Ga. This fraction diminished with time and, at 48 hr, desferrioxamine caused no significant clearance of tumor-bound ⁶⁷Ga.