Differential Effects of Chronic Nicotine and Tobacco Smoke Administration on Iliac Vascular Resistance in the Rat 1 2

Abstract

Summary

In summary these studies have demonstrated that chronic nicotine consumption by oral administration elicits a reduction in vascular resistance within the iliac circulation of the rat. The mechanism appears to involve a change in the vascular architecture as opposed to modification of vascular tone. By contrast long-term consumption of an equivalent amount of nicotine via tobacco smoke had no significant effect.