Abstract
Summary
Three inbred strains of mice, AKR/J, SWR/J, and C57BL/6J, showing differential response to dimethylhydrazine (DMH)-induced colorectal tumors, were given SC injections once a week for 10 weeks with 20 mg methylazoxymethanol (MAM) acetate/kg body wt. Colorectal tumors occurred in nearly 100% of the SWR/J mice and 77% of C57BL/6J mice that survived 20 or more weeks after the first injection. Three C57BL/6J mice and 1 SWR/J mouse developed anal tumors. None of the AKR/J mice developed colorectal or anal tumors; a possible factor here could have been the earlier deaths of animals, mostly from leukemia. The influence of genetic background on the susceptibility to MAM acetate-induced colorectal tumors is discussed.
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