Abstract
Summary
Isolated rat hepatocytes were found to adsorb (nonspecific binding) as well as to absorb chlorpromazine. The linearity of chlorpromazine adsorption was dependent on the drug concentration in the incubation medium. Also, the absorption of chlorpromazine was linear with respect to the drug concentration, suggesting an unsaturable uptake process which was considered to represent simple diffusion, with a diffusion coefficient of 0.15 nmole chlorpromazine/mg protein/min/μM. Chlorpromazine uptake was not inhibited by the action of a series of metabolic inhibitors present in the reaction medium. The drug is rapidly and to a large extent adsorbed onto hepatocellular membranes.
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