Abstract
Summary
The role of elevated renal phosphate-dependent glutaminase activity in enhancing ammonia excretion in response to an acute acid load was evaluated in adult rats. Although enzyme activity was approximately threefold higher in “adapted” rats, ammonia excretion rate during the 24 hr following administration of an acute acid load was not significantly greater than from rats with normal enzyme activity. This observation represents an example of dissociation between elevated phosphate-dependent glutaminase activity and ammonia excretion response to an acute acid load.
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