Abstract
Summary
Forty-five minutes after ip injection of chlordiazepoxide, vesicles from rat brain cortical synaptosomes contained significantly less calcium per unit protein than controls. By contrast, a relatively high dose of chlorpromazine failed to change calcium content in rat brain cortical subfractions. A high dose of theophylline increased calcium in both vesicles and mitochondria isolated from rat brain cortical synaptosomes. It is suggested that chlordiazepoxide and high doses of theophylline may influence calcium mediation of transmitter secretion in brain cortex by effects on calcium transfer mechanisms.
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