Abstract
Summary
In an effort to find animal models for serine antimetabolite studies, we examined the serine requirement of bone marrow cells of the dog, cat, rabbit, guinea pig, rat, and mouse. From measurements of radioactive precursor uptake, we found that extrinsic serine is required for optimum in vitro macromolecular synthesis by dog and rabbit marrow cells. Marrow cells from the other animals did not require extrinsic serine. It appears that the dog and rabbit would make suitable in vivo test systems for serine antimetabolite studies.
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