Abstract
Summary
The effect of lipids on taurocholate absorption was studied in the rat small intestine. It was found that: (1) experimental pancreatic insufficiency induced by a 95% pancreatectomy or by a pancreatic fistula did not lead to impairment of bile acid transport in response to an increase in fat intake; (2) the ileal absorption of water, Na+, D-xylose and taurocholate was normal in response to an emulsion of triolein and impaired by a micellar solution of oleic acid—monoolein; (3) fatty acids and monoglycerides interfere with ileal bile acid absorption particularly if they form mixed micelles with bile acids. These data do not support the hypothesis that unhydrolyzed triglycerides account for the increased loss of bile acids in CF and suggest that unabsorbed lipolytic products reaching the ileum can adversely affect bile acid transport.
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