Abstract
Summary
Hypophysial isografts stimulated mammary HAN formation and tumorigenesis in MTV-expressed female mice, even when the grafts were removed at 21-23 days of age. Exposure to the grafts (presumably secreting prolactin) during shortterm postnatal periods may induce proliferation of mammary tissue and result in early onset of mammary tumorigenesis, either directly or through the animal's endocrine system. This exposure also results in increased occurrence of uterine cyst formation in SHN mice.
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