Abstract
Summary
X-strophanthin, infused through the portal vein inflow tubing of the isolated perfused rat liver at the doses of 0.5, 2, 4 or 8 mg min-1, diminishes canalicular bile flow and hepatic perfusate flow in a dose-related fashion. For values of perfusate flow declining in the range 3.0-0.15 ml min-1 g-1 liver the diminution of bile flow is linearly related to the reduction of hepatic perfusate flow. The results suggest that the alterations in hepatic hemodynamics induced by the glycoside most likely contribute to, if not determine, the impaired secretory activity of the liver.
Get full access to this article
View all access options for this article.