Abstract
Summary
Clofibrate, a known inhibitor of cholesterol synthesis in the liver, was found effective in inhibiting cholesterol synthesis in the ventral prostate of rats after 2, 3, 4 and 10 weeks of clofibrate treatment by oral route. Blockage of cholesterol synthesis in prostate also inhibited the DNA synthesis in the ventral prostate. When clofibrate treated castrated rats were injected with testosterone, the prostate weight, the content and the synthesis of cholesterol and DNA were not restored to levels equal to those seen in control rats. Clofibrate feeding to normal rats for 10 weeks also caused histopathological changes in the ventral prostate of rats.
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