Abstract
Summary
Pretreatment of REC cultures for 24 hr with low concentrations of estrogenic and androgenic hormones modified the expression of Ad-12 lytic activity and significantly enhanced the frequency of viral transformation. The augmented effect of the steroid compounds does not appear to be sex-dependent since both male and female REC cultures exhibited enhanced transformation. However, stimulation or inhibition of Ad-12 induced transformation in these in vitro cell systems appears to be dependent on the concentration of hormones employed. The enhancing effect of the sex steroids appears to extend beyond the in vitro transformation state. This is indicated by the markedly increased tumor production in animals implanted with 17-β-estradiol derived transformed cells.
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