On the Role of Angiotensin in the Cerebellum 1

Abstract

Summary

Deep cerebellar nuclei contain angiotensin-positive synapses and high affinity receptors for angiotensin have been found in the cerebellum. Four known central effects of angiotensin were examined after injection of the peptide into the region of the dentate-interpositus nuclei: blood pressure elevation, drinking behavior, vasopressin release and ACTH release. None of these effects could be demonstrated, although the dose of angiotensin was known to produce effects when injected at other sites. The results suggest that angiotensin actions in this cerebellar region may be distinct from its known cardiovascular and hydration effects.