Abstract
Summary
Preliminary observations in man have raised the possibility that the lysosomal acid hydrolase n-acetyl-glucosaminidase may be of value in identifying patients with renovascular hypertension. We conducted studies in an accepted animal model of renovascular hypertension. Although hypertensive animals developed proteinuria which was correlated with arterial blood pressure, no increase in the excretion of n-acetylglucosaminidase was observed. These animal data do not suggest that n-acetyl-glucosaminidase is of value in the diagnosis of renovascular hypertension.
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