Abstract
Summary
The production of virus in somatic cell hybrids between Friend erythroleukemia cells and nonerythroid mouse L cells or hepatoma cells was examined. Virus synthesis was determined by assaying particle-associated reverse transcriptase activity in the culture fluid. Virus production was found to be suppressed in the 37 hybrid clones previously shown to have complete extinction of erythroid differentiation. Treatment of the cultures with DMSO, which enhances virus release in the parental erythroleukemic cells, did not result in recovery of the ability of the hybrids to produce virus.
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