Metabolism of Selenium in Skeletal Muscle and Liver of Mice with Genetic Muscular Dystrophy 1 3

Abstract

Summary

The specific activity of glutathione peroxidase and the concentration of selenium in muscles from mice with genetic muscular dystrophy were both significantly increased over those of control mice. Following pretreatment with sodium selenite (10 μg/100 g body wt) for 3 days, the specific activity of glutathione peroxidase and the concentration of selenium in muscle from the dystrophic mice were both significantly increased over values in muscle from control mice. When the dystrophic and control mice were fed a diet deficient in selenium, both the activity of glutathione peroxidase and the selenium concentration were significantly decreased in muscle from both groups. However, the magnitude of decrease was significantly greater in the muscle from the control mice than in the muscle from the dystrophic mice. These results suggest that muscle from dystrophic mice has a greater capacity for selenium absorption and retention than does muscle from control mice.