Abstract
Summary
The antiproliferative effect of interferon was studied at various stages of pre- and postimplantation mouse embryo development. Although 3.4 × 103 reference units/ml of NDV induced mouse interferon did not inhibit development of DNA synthesis in preimplantation embryos, an inhibitory effect was first detectable in primary cell cultures derived from whole 8-day embryos. This effect reached a maximum of 36 to 44% inhibition of DNA synthesis in cells cultured from 10-day embryos and remained at the same level with cells cultured from 12, 14, and 17-day embryos. These results indicate that responsiveness to interferon is achieved in the mouse embryos by 10 days.
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