Abstract
Summary
Antinatriferic factor was isolated from VE dog plasma on high pressure liquid chromatography. The use of an enzyme inhibitor while collecting plasma reduced the presence of this factor. A reverse-phase chromatography peptide map revealed 2 peptides whose presence was directly correlated with antinatriferic activity. The results suggest that antinatriferic factor is a small acidic peptide, formed from a precursor molecule. Reverse-phase chromatography may prove to be a chemical assay for antinatriferic factor.
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