Abstract
Summary
This study indicates that the primary large homogenous dense granules of eosinophilic promyelocytes are released into the extracellular space of the marrow by exocytosis while the cell is producing new secretory granules. This process appears to occur in two steps: Initial fusion of several individual granules to form one large myeloperoxidase positive membrane-delimited body, followed by exocytotic release of the granule content. The membrane of this large secretory granule appears to be retained within the cell since empty, myeloperoxidase positive vacuolar structures remain following secretion.
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