Abstract
Summary
The results obtained in this study show that a progressive depression in the splenic T-cell population occurs in P. berghei-infected mice and that T-cell migration is abnormal also. Since the thymus and lymph nodes involute in P. berghei-infected mice (10), it is likely that the total T-cell pool is depleted in the infected mouse. The decreased ability of transplanted thymus cells to seed into the infected spleen and the decreased T-cell population may indicate that infected mice have an environment hostile to T-cell viability.
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