Abstract
Summary
The cancer chemotherapeutic and antiviral agent 9-β-D-arabinofuranosyladenine (ara-A) was examined for potential oncogenicity, using a serial line of Fischer rat embryo cells, which was previously shown to be a sensitive and accurate indicator of chemicals carcinogenic for rodents. We report here that at the concentrations tested, ara-A was not a transforming agent. Further, ara-A protected the cells from transformation induced by the known carcinogen, 3-methylcholan-threne.
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