Pyrazinoic Acid and Urate Transport in the Rat

Abstract

Summary

These results indicate that urate secretion is inhibited by PZA and that the degree of inhibition is dose dependent. In the highest dose tested (1.6 mM/kg body wt/hr), PZA not only inhibits secretion but also inhibits urate absorption. Thus, PZA appears to inhibit both urate secretion and reabsorption. The inhibition of these processes is dose dependent but not necessarily of equal sensitivity.

These studies were presented in part to the American Federation for Clinical Research, Southern Section meeting, New Orleans, LA, January 27–29, 1977, and national meeting, Washington, D.C., April 30-May 2, 1977, and have appeared in abstract form in Clin. Res. 24: 416A, 1976. The studies were supported in part by a Clinical Investigator award to Dr. Weinman and an Associate Investigator award to Dr. Frankfurt from the Veterans Administration, and were performed while Dr. Frankfurt was a Fellow in Nephrology of Baylor College of Medicine. Pyrazinoic acid was kindly supplied by Dr. George Fanelli of the Merck Institute. The authors gratefully acknowledge the technical assistance of D. Steplock, L. Hawk and S. Sansom and the secretarial assistance of P. Dunham. Dr. Wadi N. Suki provided valuable guidance and advice.