Abstract
Summary
The absolute cholesterol content and rate of cholesterol synthesis was compared in rat ventral prostates obtained from adult normal and castrated rats. Cholesterol content and synthesis reduces to about 8–12% in the ventral prostate of castrated animals as compared to normal rats. Daily testosterone injections to castrated rats elicits a sharp increase in cholesterol content which correlates with an increase in prostate weight. The rate of cholesterol synthesis per microgram of prostatic DNA increases steeply 2 days after testosterone administration and then goes down and reaches a steady state after 5 days.
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